Scientists have attributed more than 40 percent of the failures in new drug growth to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone, or utterly derail, vital new drug development. Even much-wanted reformulation of at present marketed merchandise may be significantly affected by these challenges.
Water Insolubility is the Primary Wrongdoer in over 40% of New Drug Development Failures
Probably the most comprehensive useful resource on the subject, this second edition of Water Insoluble Drug Formulation brings collectively a distinguished group of specialists to supply the scientific background and step-by-step steerage wanted to cope with solubility points in drug development. Twenty-three chapters systematically describe solubility properties and their impression on formulation, from concept to industrial practice. With detailed discussion on how these properties contribute to solubilization and dissolution, the textual content additionally options six model new chapters on water-insoluble medicine, exploring regulatory features, pharmacokinetic behavior, early section formulation methods, lipid based methods for oral delivery, modified release of insoluble drugs, and scalable manufacturing aspects. The e book includes more than 15 water-insoluble drug delivery methods or applied sciences, illustrated with case research featuring oral and parenteral applications. Highlighting the most current info and information out there, this seminal volume displays the numerous progress that has been made in nearly all aspects of this field.
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